报告题目：The role of thermal undulations in cell-biological systems
报告人：香港大学机械工程系 Yuan Lin 教授
报告时间：12月25日(周五) 下午15:00-16:00
报告地点：浙江大学玉泉校区教12-118
报告摘要：When immersed in a thermal reservoir, objects like cell membrane and actin filament are susceptible to bending deformations due to thermal excitations. These types of thermal undulations can be both disruptive and useful which will be demonstrated through two examples in this talk. First, we will show that the density of molecular bonds, connecting the cytoskeleton of a cell to the extracellular matrix, must be larger than a certain value in order to “suppress” the fluctuations of the membrane and hence enforce stable adhesion. This finding explains recent experiment observations that tight cell adhesion patches can only be formed when bonds were spaced more closely together than a critical spacing, whereas almost no adhesions between the cell and the substrate were formed for spacing larger than this critical value.
The second example concerns with the actin-based motility of cell and Listeria. We will demonstrate the essential role of thermal undulations in the generation of propelling forces, large enough for the continuous movements of cell and Listeria, by unidirectional actin polymerizations. A mechanics model is proposed to describe the force generation capability of actin filaments and the comparisons between model predictions and various experiment data will also be presented.
报告人简介：
Yuan Lin，香港大学机械工程系助理教授。1999、2001年分别从清华大学获得本科、硕士学位，2006年获美国布朗大学应用数学硕士学位，2007年底从美国布朗大学获得固体力学博士学位，导师为国际固体力学大师L. Ben Freund教授，2008年开始任教于香港大学。他的主要研究领域包括固体力学，分子和细胞生物力学等。在JMPS，IJSS，PRE，Acta Materialia等国际知名期刊上发表多篇学术论文。
欢迎大家光临！
